50-28-2

Product Details

Appearance:white or milky white ordorless crystalline powde

Throughput:2|Metric Ton|Month

pd_productuse:Estradiol is the major estrogen secreted by the premenopausal ovary.

Delivery Time:in stock

Purity:99%

 

Estradiol Usage And Synthesis
Indications and Usage Estradiol is a white or milky white ordorless crystalline powder. It is soluble in dioxane and acetone, slightly soluble in ethanol, and insoluble in water.
Estradiol is the intermediate between estradiol valerate and estradiol benzoate, and it is a type of estrogen drug. It can be used to treat uterine functional bleeding, primary amenorrhea, menopausal syndrome, and prostate cancer. Estradiol can promote and adjust the normal growth of female sex organs and secondary sex characteristics, promote mammary duct maturation and growth, and aid in posseting. Estradiol can also be used in biochemical research.
Adverse reactions In high dosages, estradiol can inhibit the release of anterior pituitary prolactin, thus decreasing breast milk secretion. However, nausea, vomiting and endometrial hyperplasia-induced bleeding may occur. Patients with liver or kidney failure should use with caution.
Contradictions Do not use on breasts, vaginal area and vaginal mucosa.
Chemical Properties White Crystalline Powder
Uses Potent mammalian estrogenic hormone produced by the ovary.
Uses Estradiol is the major estrogen secreted by the premenopausal ovary.
Definition ChEBI: The 17beta-isomer of estradiol.
Biological Activity Endogenous estrogen receptor (ER) agonist (K i values are 0.12 and 0.13 nM for ER α and ER β respectively). Also high affinity ligand at membrane estrogen GPR30 receptors.
Estradiol Preparation Products And Raw materials
Raw materials Nitrogen-->p-Toluenesulfonic acid-->Litium-->Potassium borohydride-->Biphenyl-->Acetylacetone-->1,3,5(10)-Estratrien-3-ol-17-one-->Diphenylmethane-->4-ETHYL-2-METHYLPYRIDINE-->ADD