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Appearance:powder
Throughput:100|Kilogram|Month
pd_productuse:intermediate
Delivery Time:in stock
Purity:98% purity
Melting point -13°C(lit.)
Boiling point 106.5 °C/3 mmHg (lit.)
density 1.119 g/mL at 25 °C (lit.)
refractive index n20/D 1.435(lit.)
Fp >230 °F
storage temp. Sealed in dry,Room Temperature
pka pK1:3.55 (25°C)
form Liquid
color Pale yellow
Water Solubility Miscible with water, chloroform and other solvents.
BRN 1758845
InChIKey HGINADPHJQTSKN-UHFFFAOYSA-N
CAS DataBase Reference 1071-46-1(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36
WGK Germany 3
HS Code 29171900
Chemical Properties Yellow liquid
Uses Ethyl Hydrogen Malonate has been shown to impair brain mitochondrial succinate and malate transport. It is also found in the extract of Hericum erinaceus mushroom which shows antitumor effects in tumo r-bearing mice.
Uses Ethyl hydrogen malonate is used as a reactant for the preparation of tetramic acids through Dieckmann ring closure and organocatalytic decarboxylative Doebner-Knoevenagel reactions. It is involved in the acylation reactions and Knoevenagel condensation with aldehydes. It is also used in the preparation of gamma-lactones from olefins by intermolecular carbolactonization in presence of Mn(III) acetate as a catalyst.
Synthesis Reference(s) Organic Syntheses, Coll. Vol. 4, p. 417, 1963
Tetrahedron Letters, 26, p. 1411, 1985 DOI: 10.1016/S0040-4039(00)99058-0
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