Your Location：Home >Products >Fine Chemicals >48208-26-0
Appearance:powder
Throughput:100|Kilogram|Day
pd_productuse:intermediate
Delivery Time:in stock
Purity:99% purity
Melting point 192-194℃
Boiling point 606.0±50.0 °C(Predicted)
density 1.502±0.06 g/cm3(Predicted)
storage temp. -20°C
solubility DMSO: >10mg/mL
pka 3.62±0.10(Predicted)
form powder
color yellow
Sensitive Light Sensitive
CAS DataBase Reference 48208-26-0
Safety Information
WGK Germany 3
MSDS Information
RG108 Usage And Synthesis
Uses DNA methylation regulates gene expression in normal and malignant cells. RG-108 is a non-nucleoside DNA methyltransferase inhibitor (IC50 = 115 nM in vitro). It significantly reduces the methylation of genomic DNA in cells at 10 μM without detectable toxicity, distinguishing it from nucleoside-based inhibitors like 5-azacytidine. Further, RG-108 inhibits DNA methyltransferase activity by blocking the enzyme active site. Through these actions, RG-108 demethylates and reactivates epigenetically silenced tumor suppressor genes.
Biological Activity Non-nucleoside DNA methyltransferase inhibitor that blocks the enzyme active site. Inhibits DNA methylation in human cancer cell lines in vitro without detectable toxicity. Demethylates and reactivates epigenetically silenced tumor suppressor genes.
CAS：885523-08-0
CAS：517920-73-9
CAS：97-90-5
CAS：944401-77-8
