446-72-0

Product Details

Appearance:Yellow Crystalline Solid

Throughput:20|Metric Ton|Month

pd_productuse:Exhibits specific inhibitory activity against tyrosine kinases,including autophosphorylation of epidermal growth factor receptor kinase (IC50 - 2.6uM). Also inhibits other protein kinases through comp

Delivery Time:in stock

Purity:99.00%

Genistein Chemical Properties

mp  297-298 °C 
storage temp.  −20°C

solubility  DMSO: soluble

form  powder

color  off-white

Water Solubility  insoluble
Merck  14,4391
BRN  263823
Stability: Light Sensitive
CAS DataBase Reference 446-72-0(CAS DataBase Reference)
EPA Substance Registry System 4H-1-Benzopyran- 4-one, 5,7-dihydroxy-3-(4-hydroxyphenyl)- (446-72-0)

Safety Information

Hazard Codes  Xi
Risk Statements  36/38
Safety Statements  26-24/25-22
WGK Germany  3

RTECS  NR2392000

HazardClass  IRRITANT
Hazardous Substances Data 446-72-0(Hazardous Substances Data)

Genistein Usage And Synthesis

Chemical Properties Yellow Crystalline Solid
Usage Exhibits specific inhibitory activity against tyrosine kinases,including autophosphorylation of epidermal growth factor receptor kinase (IC50 - 2.6uM). Also inhibits other protein kinases through competitive inhibition of ATP. Inhibits tumor cell proliferation and induces tumor cell differentiation. Produces cell-cycle arrest and apoptosis in Jurat T-leukemia cells. However, it prevents anti-CD3 monoclonal antibody-induced thymic apoptosis. Genistein also inhibits topoisomerase II activity in vitro. Genistein has also been shown to inhibit the action of GABA on recombinant GABAA receptors 2. uv(max)ethanol: 262.5 nm (e= 138). moderately sol. in hot alcohol
Usage Genistein, a phytoestrogen found in soy products, is a highly specific inhibitor of protein tyrosine kinase (PTK) which blocks the mitogenic effect mediated by EGF on NIH-3T3 cells with IC50 of 12μM or by insulin with IC50 of 19 μM.
Usage cytotoxic inhibitor of tyrosine kinase and topoisomerase II kinase
Biological Activity Phytoestrogen with a wide range of biological actions. Inhibits protein tyrosine kinases including epidermal growth factor receptor kinase. Also binds to PPAR γ and estrogen receptors and acts as an agonist at GPR30. Also available as part of the MAPK Cascade Inhibitor Tocriset™ .

Genistein Preparation Products And Raw materials

Raw materials Diethyl ether