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Appearance:powder
Throughput:100|Kilogram|Month
pd_productuse:intermediate
Delivery Time:in stock
Purity:99% purity
Melting point 255-256.5°C
alpha D +62.3° (c = 0.5 in chloroform)
Boiling point 595.4±50.0 °C(Predicted)
density 1.41
storage temp. 2-8°C
solubility DMSO: ≥20mg/mL
pka 14.30±0.70(Predicted)
form powder
color white to tan
Merck 14,2862
Safety Information
Safety Statements 24/25
WGK Germany 3
RTECS TU4157050
HS Code 29349990
Toxicity LD50 orally in mice: 5200 mg/kg (Schiatti)
Description Deflazacort (trade name Emflaza among others) is a glucocorticoid used as an anti-inflammatory and immunosuppressant. It belongs to a group of medicines called corticosteroids. It is sometimes referred to simply as an oral steroid.
Deflazacort is an inactive prodrug which is metabolized rapidly to the active drug 21-desacetyldeflazacort.It is used to treat a wide variety of conditions. Some examples include autoimmune diseases (for example, systemic lupus erythematosus (SLE), autoimmune hepatitis, sarcoidosis), joint and muscle diseases (for example, rheumatoid arthritis), and allergies and asthma.
Cardiff can be specially designed for the third generation of corticosteroids, anti-inflammatory, anti-allergy, and it increased gluconeogenesis and so on. It acts as prednisolone 10~20 times of the dragon, 40 times as hydrocortisone. This product has no mutagenic effect. This product, labeled with C14 study, shows that the product of the gastrointestinal tract rapidly absorbed, reaching the peak blood concentration after 1~2h, forming the active substance by hydrolysis, and the latter further metabolic processes is similar with other corticosteroids, as well as the active metabolite T1/2 is 2 h and the rats are mainly distributed in the kidney and hematopoietic system and other organizations.
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