168547-43-1

Product Details

Appearance:Powder

Throughput:100|Metric Ton|Day

pd_productuse:intermediate

Delivery Time:instock

Purity:99.9

Melting point     86-89 °C (lit.)
Boiling point     125 °C (lit.)
density     0.87 g/mL at 20 °C(lit.)
refractive index     n20/D 1.46
Fp     73 °F
storage temp.     Store at 5°C
form     Liquid
color     Clear colorless
Specific Gravity    1.225
Water Solubility     Soluble in chloroform and ethyl acetate. Insoluble in water.
Sensitive     Moisture Sensitive
Hydrolytic Sensitivity    7: reacts slowly with moisture/water
Hydrolytic Sensitivity    8: reacts rapidly with moisture, water, protic solvents
BRN     505999
InChIKey    BCNZYOJHNLTNEZ-UHFFFAOYSA-N
CAS DataBase Reference    18162-48-6(CAS DataBase Reference)
NIST Chemistry Reference    Silane, chloro(1,1-dimethylethyl)dimethyl-(18162-48-6)
EPA Substance Registry System    Silane, chloro(1,1-dimethylethyl)dimethyl- (18162-48-6)
Safety Information
Hazard Codes     C,F,T,Xn
Risk Statements     22-35-40-34-10-19-11-67-65-63-48/20-20/21/22-45-23/24/25-37-36/37/38
Safety Statements     26-36/37/39-46-62-45-25-16-28-27-33-29-53-36/37
RIDADR     UN 2925 4.1/PG 2
WGK Germany     2
RTECS     VV2000000
F     10-21
Hazard Note     Flammable/Corrosive/Moisture Sensitive
TSCA     Yes
HazardClass     4.1
PackingGroup     III
HS Code     29310095
MSDS Information
Provider    Language
TBDMCS    English
SigmaAldrich    English
ACROS    English
ALFA    English

tert-Butyldimethylsilyl chloride Usage And Synthesis
Introduction    Triethylchlorosilane is a clear, colourless to yellowish, pungent smelling, caustic and flammable liquid. It can be dissolved in non-protonating solvents without decomposition.
It may be used as silylating agent for dervatization of primary and secondary alcohols etc.. Also it may be used to protect allylic esters as silylketene acetal which is ore stable but less volatile derivates than trimethylchlorosilane.
Chemical Properties    White solid
Uses    Used to protect alcohols during organic synthesis.
Definition    ChEBI: A silyl chloride consisting of a central silicon atom covalently bound to one chloro, one tert-butyl and two methyl groups. tert-Butyldimethylsilyl chloride is a derivatisation agent used in gas chromatography/mass spectrometry ap lications.
Hazard    Moderately toxic.
Purification Methods    Fractionally distil it at atmospheric pressure. [Sommer & Tyler J Am Chem Soc 76 1030 1954, Corey & Venkateswarlu J Am Chem Soc 94 6190 1972, Beilstein 4 IV 4076.]
tert-Butyldimethylsilyl chloride Preparation Products And Raw materials
Raw materials    Pentane-->tert-Butyllithium-->Dichlorodimethylsilane
Preparation Products    5-(AMINOMETHYL)-1-METHYLPYRROLIDIN-2-ONE-->(3S,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one-->beta-Methyl vinyl phosphate (MAP)-->2-CYANOPYRIDINE-4-CARBOXALDEHYDE-->4-(HYDROXYMETHYL)PICOLINITRILE-->Simvastatin-->2-Chloro-4-nitrophenyl-alpha-L-fucopyranoside-->4-Mercaptophenylboronic acid-->Montelukast-->Trifluoromethanesulfonic acid tert-butyldimethylsilyl ester-->Calcipotriene-->BIS(T-BUTYLDIMETHYLSILOXY)ETHANE