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Appearance:powder
Throughput:100|Kilogram|Day
pd_productuse:intermediate
Delivery Time:in stock
Purity:98% purity
Birinapant Chemical Properties
Boiling point 1090.5±65.0 °C(Predicted)
density 1.320±0.06(20.0000℃)
pka 13.99±0.46(Predicted)
CAS DataBase Reference 1260251-31-7
Safety Information
HS Code 29339900
MSDS Information
Birinapant Usage And Synthesis
Enzyme inhibitor This rotationally symmetric SMAC mimetic antagonist and anticancer agent (FW = 806.94 g/mol; CAS 1260251-31-7) targets cellular Inhibitor of Apoptosis Protein (or cIAP1; Kd of <1 nM), arguably the most potent mammalian caspase inhibitor, showing single-agent efficacy due to its panIAP antagonism and causing rapid cIAP1 degradation, caspase activation, PARP cleavage, and NF-κB activation. When administered in combination with TNF-α, Birinapant is effective against a melanoma cell line with acquired resistance to BRAF inhibitors
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