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Appearance:powder
Throughput:100|Kilogram|Day
pd_productuse:intermediate
Delivery Time:in stock
Purity:98% purity
TAK-960 Chemical Properties
density 1.39±0.1 g/cm3(Predicted)
pka 13.21±0.20(Predicted)
Safety Information
MSDS Information
TAK-960 Usage And Synthesis
Uses TAK-960 is a potent and selective inhibitor of polo-like kinase 1 (PLK1), a serine/threonine protein kinase involved in key processes during mitosis. TAK-960 has shown activity in several tumor cell l ines, including those that express multidrug-resistant protein 1 (MDR1). TAK-960 treatments has shown significant efficacy against multiple tumor xenografts and is a potential chemotherapeutic agent f or patients with advanced tumors.
TAK-960 Preparation Products And Raw materials
Raw materials Benzamide, 4-amino-2-fluoro-5-methoxy-N-(1-methyl-4-piperidinyl)--->2-CHLORO-9-CYCLOPENTYL-7,7-DIFLUORO-5-METHYL-8,9-DIHYDRO-5H-PYRIMIDO[4,5-B][1,4]DIAZEPIN-6(7H)-ONE-->1-Methylpiperidin-4-amine-->2-Fluoro-5-methoxy-4-nitrobenzoic acid-->ethyl3-(cyclopentylamino)-2,2-difluoropropanoate-->2-chloro-9-cyclopentyl-7,7-difluoro-5,8-dihydropyrimido[4,5-b][1,4]diazepin-6-one-->Benzoic acid, 2,5-difluoro-4-nitro-, Methyl ester-->Cyclopentylamine
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