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Appearance:powder
Throughput:100|Kilogram|Day
pd_productuse:intermediate
Delivery Time:in stock
Purity:98% purity
Melting point 177-181 °C
Boiling point 257 °C (13 mmHg)
density 1.2082 (rough estimate)
refractive index 1.5434 (estimate)
Fp 100 °C
storage temp. Inert atmosphere,Room Temperature
pka 7.68±0.15(Predicted)
form neat
BRN 2049956
CAS DataBase Reference 42019-78-3(CAS DataBase Reference)
NIST Chemistry Reference Methanone, (4-chlorophenyl)(4-hydroxyphenyl)-(42019-78-3)
Safety Information
Hazard Codes Xi,Xn
Risk Statements 36/37/38-20/21/22
Safety Statements 24/25-37/39-26-36
Hazard Note Irritant
HS Code 29144000
MSDS Information
Provider Language
(4-Chlorophenyl)(4-hydroxyphenyl)-Methanone English
ACROS English
ALFA English
4-Chloro-4'-hydroxybenzophenone Usage And Synthesis
Chemical Properties light grey to beige-brown powder
Uses The Impurity of Fenofibric acid (42017-89-0), the active metabolite of fenofibrate which increases Apolipoprotein A-I–Mediated High-Density Lipoprotein Biogenesis by enhancing transcription of ATP-Binding cassette transporter A1 gene in a liver X receptor
Preparation Preparation by Fries rearrangement of phenyl p-chloro-benzoate,
in the presence of aluminium chloride, without solvent, at 160° for 5 min, between 120° and 160° (good yield) or at 130° for 1 h, then at 160° for 1 h (10%) or in refluxing chlorobenzene for 10 h (52%);
in the presence of trifluoromethanesulfonic acid at 45–55° (94%).
4-Chloro-4'-hydroxybenzophenone Preparation Products And Raw materials
Raw materials Aluminum chloride-->Anisole-->4-Chlorobenzoyl chloride-->4-Chlorophenylacetylene-->4-chloro-4'-methoxybenzophenone-->SYN-BENZALDEHYDE OXIME-->4-chloro-4'-fluorobenzophenone-->4-CHLORO-4'-NITROBENZOPHENONE
Preparation Products Fenofibric acid
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