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14648-57-8

Product Name:2-Ethyl-2-adamantanol
Molecular Formula:C₁₂H₂₀O

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Product Details

Purity:99%

High Purity 2-Ethyl-2-adamantanol 14648-57-8

14648-57-8 Name
Name	2-Ethyl-2-adamantanol
Synonym	2-ETHYL-2-HYDROXYTRICYCLO[3,3,1,1(3,7)])DECANE;2-ETHYL-2-HYDROXYADAMANTANE;2-Ethyl-2-hydroxyadamantane 95+%;2-Ethyl-2-adamantanol 14648-57-8;2-Ethyl-2-adamantanol 99.9% In stock;2-Ethyl-2-adamantanol ,99%;2-Ethyl-2-adamantane;2-Ethyl-2-adamantanol

14648-57-8 Chemical & Physical Properties
Melting point	70 °C
Boiling point	265.5±8.0 °C at 760 mmHg
Density	1.0±0.1 g/cm3
Molecular Formula	C12H20O
Molecular Weight	180.287
Flash Point	110.2±10.9 °C
PSA	20.23000
LogP	3.25
Exact Mass	180.151413
Vapour Pressure	0.0±1.2 mmHg at 25°C
Index of Refraction	1.527

Pharmaceutical Intermediates 2-Ethyl-2-adamantanol 14648-57-8 Usage

2-Ethyl-2-adamantanol is White crystal. The reaction of 2-ethyl-2-adamantanol with the same reagent yields a mixture of compounds from which 2-adamantanone, 2-(1-acetoxyethyl)-2- adamantanol, and products of stabilization of 2-(1-nitroethyl)-2-adamantyl cation were isolated.

InChI:InChI=1/C12H20O/c1-2-12(13)10-4-8-3-9(6-10)7-11(12)5-8/h8-11,13H,2-7H2,1H3

14648-57-8 Relevant articles

Molecular design and characterization of high-cetane alkyl diamondoid fuels

Benjamin G. Harvey*, Kale W. Harrison, Matthew C. Davis, Andrew P. Chafin, Joshua Baca, and Walter W. Merriman

Energy Fuels 2016, 30, 12, 10171–10178

Commercially available 2-ethyl-2-adamantanol was dehydrated and hydrogenated to yield EA. The alkyl diamondoids described in this report are the first examples of multicyclic hydrocarbons that combine extraordinary densities (>0.9 g/mL) with DCNs comparable to or exceeding that of conventional diesel fuel.

Comparisons of the influenza virus A M2 channel binding affinities, anti-influenza virus potencies and NMDA antagonistic activities of 2-alkyl-2-aminoadamantanes and analogues

Kolocouris, Antonios,Spearpoint, Philip,Martin, Stephen R.,Hay, Alan J.,Lopez-Querol, Marta,Sureda, Francesc X.,Padalko, Elizaveta,Neyts, Johan,De Clercq, Erik

scheme or table, p. 6156 - 6160 (2009/09/06)

1. The relative binding affinities suggested that the rigid carbon framework provided by the pyrrolidine or piperidine rings results in a more favorable orientation inside the M2 channel pore as compared to large, freely rotating alkyl groups. The aminoadamantane derivatives exhibited similar NMDA antagonistic activity to amantadine 1. A striking finding was the antiviral activity of the adamantanols 4, and 6, which lack any NMDA antagonist activity.

14648-57-8 Process route

: 700-58-3
2-Adamantanone

: 925-90-6
ethylmagnesium bromide

: 700-57-2
1-adamantanol

: 14648-57-8
2-ethyl-2-adamantanol

Conditions

Conditions	Yield
ethylmagnesium bromide; With (trimethylsilyl)methylmagnesium chloride; lithium chloride; zinc(II) chloride; In tetrahydrofuran; diethyl ether; at 20 ℃; 2-Adamantanone; In tetrahydrofuran; diethyl ether; at 0 ℃; for 3h;	80% 16%
In tetrahydrofuran; diethyl ether; at 0 ℃;	80% 18%