Purity:99%
β-Nicotinamide Mononucleotide (“NMN” and “β-NMN”), an Anti-Aging Candidate Compound, Is Retained in the Body for Longer than Nicotinamide in Rats and it is a NAD+intermediate. β-Nicotinamide mononucleotide (NMN) has been widely used as a nutraceutical for self-medication. NMN and NR have been suggested to bind to ACE2 and IMPDH, along with SARS-CoV-2 viral proteins (Spro, Mpro, PLpro, RdRp) by molecular docking and dynamics simulations, suggesting a potential therapeutic effect of NMN and NR in the treatment of COVID-19.
InChI:InChI=1/C11H15N2O8P/c12-10(16)6-2-1-3-13(4-6)11-9(15)8(14)7(21-11)5-20-22(17,18)19/h1-4,7-9,11,14-15H,5H2,(H3-,12,16,17,18,19)/t7-,8-,9-,11-/m1/s1
These foundational data that were obtained using a pharmaceutical-grade β Nicotinamide mononucleotide (NMN), standardized sample collection, and validated liquid chromatography–tandem mass spectrometry assays, should facilitate design of efficacy trials in disease conditions.
In animal studies, β-nicotinamide mononucleotide (NMN) supplementation increases nicotinamide adenine dinucleotide (NAD) concentrations and improves healthspan and lifespan with great safety. The primary objective was to evaluate blood NAD concentration with dose-dependent regimens.
NAD
nicotinamide mononucleotide
adenosine 5'-diphosphate
adenosine
| Conditions | Yield |
|---|---|
|
With water; zirconium(IV) oxide; at 80 ℃; for 48h;
|
3-carbamoyl-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyridin-1-ium (β-D-nicotinamide riboside)
nicotinamide mononucleotide
| Conditions | Yield |
|---|---|
|
With trimethyl phosphite; trichlorophosphate; at 0 ℃; for 12h; Inert atmosphere;
|
88.27% |
|
3-carbamoyl-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyridin-1-ium (β-D-nicotinamide riboside); With Sodium trimetaphosphate; sodium hydroxide; In water; at 30 ℃; for 4h; pH=9;
With hydrogenchloride; In water; at 10 ℃; Reagent/catalyst;
|
68% |
|
With nitromethane; water; trichlorophosphate;
|
|
|
With trichlorophosphate;
|
|
|
With trimethyl phosphite; trichlorophosphate; at -10 - -7 ℃; for 24h; Temperature;
|
10 g |
|
Multi-step reaction with 2 steps
1: pyridine / acetonitrile / 12 h / 0 - 5 °C
2: platinum(IV) oxide; hydrogen / deuteromethanol / 12 h
With pyridine; platinum(IV) oxide; hydrogen; In deuteromethanol; acetonitrile;
|
3-carbamoyl-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyridin-1-ium (β-D-nicotinamide riboside)
nicotinamide
5-phosphoribosyl-1-pyrophosphate
NAD
4'-(3-
4'-(6-
nicotinamide
C27H42N9O17P3
Direct Factory Supply Top Purity Cosmetics NMN 1094-61-7, Wholesale β-Nicotinamide Mononucleotide 1094-61-7 In Stock, In Bulk Supply
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