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1094-61-7

  • Product Name:NMN
  • Molecular Formula:C11H15 N2 O8 P
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Product Details

Purity:99%

Direct Factory Supply High Quality β-Nicotinamide Mononucleotide 1094-61-7, Cheap Price

  • Molecular Formula:C11H15 N2 O8 P
  • Molecular Weight:334.222
  • Boiling Point:°Cat760mmHg 
  • Flash Point:°C 
  • PSA：176.06000 
  • Density:g/cm3 
  • LogP:-1.06000 

In Bulk Supply, Wholesale Top Purity Cosmetics NMN 1094-61-7 In Stock

β-Nicotinamide Mononucleotide (“NMN” and “β-NMN”), an Anti-Aging Candidate Compound, Is Retained in the Body for Longer than Nicotinamide in Rats and it is a NAD+intermediate. β-Nicotinamide mononucleotide (NMN) has been widely used as a nutraceutical for self-medication. NMN and NR have been suggested to bind to ACE2 and IMPDH, along with SARS-CoV-2 viral proteins (Spro, Mpro, PLpro, RdRp) by molecular docking and dynamics simulations, suggesting a potential therapeutic effect of NMN and NR in the treatment of COVID-19.

 

InChI:InChI=1/C11H15N2O8P/c12-10(16)6-2-1-3-13(4-6)11-9(15)8(14)7(21-11)5-20-22(17,18)19/h1-4,7-9,11,14-15H,5H2,(H3-,12,16,17,18,19)/t7-,8-,9-,11-/m1/s1

1094-61-7 Relevant articles

MIB-626, an Oral Formulation of a Microcrystalline Unique Polymorph of β-Nicotinamide Mononucleotide, Increases Circulating Nicotinamide Adenine Dinucleotide and its Metabolome in Middle-Aged and Older Adults

Karol M Pencina, PhD, Siva Lavu, PhD, Marcello dos Santos, PhD, Yusnie M Beleva, BSc, Ming Cheng, MS, David Livingston, PhD, Shalender Bhasin, MBBS

The Journals of Gerontology: Series A, Volume 78Issue 1 January 2023

These foundational data that were obtained using a pharmaceutical-grade β Nicotinamide mononucleotide (NMN), standardized sample collection, and validated liquid chromatography–tandem mass spectrometry assays, should facilitate design of efficacy trials in disease conditions.

The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial

Yi, Lin，Maier, Andrea B.，Tao, Rongsheng，Lin, Zhigang，Vaidya, Aditi，Pendse, Sohal，Thasma, Sornaraja，Andhalkar, Niranjan，Avhad, Ganesh，Kumbhar, Vidyadhar

, p. 1215 - 1216 (1994)

In animal studies, β-nicotinamide mononucleotide (NMN) supplementation increases nicotinamide adenine dinucleotide (NAD) concentrations and improves healthspan and lifespan with great safety. The primary objective was to evaluate blood NAD concentration with dose-dependent regimens.

1094-61-7 Process route

NAD
53-84-9,66844-06-2

NAD

nicotinamide mononucleotide
1094-61-7

nicotinamide mononucleotide

adenosine 5'-diphosphate
58-64-0,905904-58-7

adenosine 5'-diphosphate

adenosine
58-61-7

adenosine

Conditions
Conditions Yield
With water; zirconium(IV) oxide; at 80 ℃; for 48h;
 
3-carbamoyl-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyridin-1-ium (β-D-nicotinamide riboside)
23111-00-4

3-carbamoyl-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyridin-1-ium (β-D-nicotinamide riboside)

nicotinamide mononucleotide
1094-61-7

nicotinamide mononucleotide

Conditions
Conditions Yield
With trimethyl phosphite; trichlorophosphate; at 0 ℃; for 12h; Inert atmosphere;
88.27%
3-carbamoyl-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyridin-1-ium (β-D-nicotinamide riboside); With Sodium trimetaphosphate; sodium hydroxide; In water; at 30 ℃; for 4h; pH=9;
With hydrogenchloride; In water; at 10 ℃; Reagent/catalyst;
68%
With nitromethane; water; trichlorophosphate;
 
With trichlorophosphate;
 
With trimethyl phosphite; trichlorophosphate; at -10 - -7 ℃; for 24h; Temperature;
10 g
Multi-step reaction with 2 steps
1: pyridine / acetonitrile / 12 h / 0 - 5 °C
2: platinum(IV) oxide; hydrogen / deuteromethanol / 12 h
With pyridine; platinum(IV) oxide; hydrogen; In deuteromethanol; acetonitrile;
 

1094-61-7 Upstream products

  • 23111-00-4
    23111-00-4

    3-carbamoyl-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyridin-1-ium (β-D-nicotinamide riboside)

  • 98-92-0
    98-92-0

    nicotinamide

  • 97-55-2
    97-55-2

    5-phosphoribosyl-1-pyrophosphate

  • 53-84-9
    53-84-9

    NAD

1094-61-7 Downstream products

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    98-92-0

    nicotinamide

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    193698-75-8

    C27H42N9O17P3

Direct Factory Supply Top Purity Cosmetics NMN 1094-61-7, Wholesale β-Nicotinamide Mononucleotide 1094-61-7 In Stock, In Bulk Supply

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