2-Bromo-4-chloro-1-iodobenzene

Basic information

Product Name:2-Bromo-4-chloro-1-iodobenzene
CasNo.:31928-44-6
Molecular Formula:C₆H₃BrClI
Molecular Weight:

Physical and Chemical Properties

Purity:99%
Boiling Point:
Packing:
Throughput:

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Product Details

CasNo： 31928-44-6

Molecular Formula： C₆H₃BrClI

2-Bromo-4-chloro-1-iodobenzene 31928-44-6 In Bulk Supply, Best Price

31928-44-6 Name
Name	2-Bromo-4-chloro-1-iodobenzene
Synonym	2-BROMO-4-CHLORO-1-IODOBENZENE;2-Bromo-1-iodo-4-chlorobenzene;1-Iodo-2-bromo-4-chlorobenzene;2-Bromo-4-chloro-1-iodobenzene >;Benzene, 2-bromo-4-chloro-1-iodo-

31928-44-6 Chemical & Physical Properties
Melting point	32-35°C
Boiling point	278.9±20.0 °C at 760 mmHg
Density	2.3±0.1 g/cm3
Molecular Formula	C6H3BrClI
Molecular Weight	317.349
Flash Point	122.5±21.8 °C
LogP	4.41
Exact Mass	315.815125
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.663

2-Bromo-4-chloro-1-iodobenzene 31928-44-6 Usage

2-Bromo-4-chloro-1-iodobenzene is a compound of Organic Building Blocks research chemicals for sale.

InChI:InChI=1/C6H3BrClI/c7-5-3-4(8)1-2-6(5)9/h1-3H

31928-44-6 Relevant articles

Method for the synthesis of phenothiazines via a domino iron-catalyzed C–S/C–N cross-coupling reaction

W Hu, S Zhang

J. Org. Chem. 2015, 80, 12, 6128–6132

It is noteworthy that the reactions of 2-bromo-4-chloro-1-iodobenzene and 4-chloro-1,2-diiodobenzene resulted in a mixture of two regioisomers in both cases in a high total yield (Table …An environmentally benign and efficient method has been developed for the synthesis of phenothiazines via a tandem iron-catalyzed C–S/C-N cross-coupling reaction.

Direct Transformation of Arylamines to Aryl Halides via Sodium Nitrite and N-Halosuccinimide

Mukhopadhyay, Sushobhan,Batra, Sanjay

supporting information, p. 14622 - 14626 (2018/09/21)

A one-pot universal approach for transforming arylamines to aryl halides via reaction with sodium nitrite (NaNO2) and N-halosuccinimide (NXS) in DMF at room temperature under metal- and acid-free condition is described. This new protocol that is complementary to the Sandmeyer reaction, is suggested to involve the in situ generation of nitryl halide induce nitrosylation of aryl amine to form the diazo intermediate which is halogenated to furnish the aryl halide.

31928-44-6 Process route

: 873-38-1
4-chloro-2-bromoaniline

: 31928-44-6
2-bromo-4-chloroiodobenzene

Conditions

Conditions	Yield
4-chloro-2-bromoaniline; With hydrogenchloride; sodium nitrite; In water; at -15 - 0 ℃; for 0.833333h; With potassium iodide; In water; at 20 ℃; for 6.17h;	81%
With N-iodo-succinimide; sodium nitrite; In N,N-dimethyl-formamide; at 20 ℃; for 4h;	78%
4-chloro-2-bromoaniline; With hydrogenchloride; In water; at 80 ℃; for 1h; With sodium nitrite; In water; at -5 ℃; for 1.5h; With potassium iodide; In water; at 0 - 20 ℃; for 40h;	67%
4-chloro-2-bromoaniline; With hydrogenchloride; sodium nitrite; at 0 ℃; for 0.5h; With potassium iodide; In water; at 20 ℃; for 12h; Further stages.;	50%
4-chloro-2-bromoaniline; With hydrogenchloride; In water; at 80 ℃; With sodium nitrite; In water; at 0 ℃; for 1h; With potassium iodide; In water; at 10 - 60 ℃;	50%
With sulfuric acid; potassium iodide; sodium nitrite; Multistep reaction; 1.) water, 10 deg C, 30 min, 2.) water 60 deg C;
4-chloro-2-bromoaniline; With sulfuric acid; sodium nitrite; In water; at 0 ℃; for 2h; Inert atmosphere; With copper(l) iodide; potassium iodide; In water; at 0 - 20 ℃; Inert atmosphere;	18.8 g
With hydrogenchloride; potassium iodide; sodium nitrite; In water; at -15 - 20 ℃; for 18.5h;	16.4 g
Multi-step reaction with 2 steps 1: tert.-butylnitrite / dichloromethane; tetrahydrofuran / 0.58 h / -20 - 0 °C 2: pyridine; iodine / acetonitrile / 2 h / -30 - 25 °C With pyridine; tert.-butylnitrite; iodine; In tetrahydrofuran; dichloromethane; acetonitrile;