METHYL 2,4-DIHYDROXY-6-PENTYLBENZOATE

Basic information

Product Name:METHYL 2,4-DIHYDROXY-6-PENTYLBENZOATE
CasNo.:58016-28-7
Molecular Formula:C13H18O4
Molecular Weight:

Physical and Chemical Properties

Purity:99%
Boiling Point:
Packing:
Throughput:

Inquiry

Product Details

CasNo： 58016-28-7

Molecular Formula： C13H18O4

Pharmaceutical Intermediates METHYL 2,4-DIHYDROXY-6-PENTYLBENZOATE 58016-28-7 Global Trade

58016-28-7 Name
Name	METHYL 2,4-DIHYDROXY-6-PENTYLBENZOATE
Synonym	methyl 2,4-dihydroxy-6-pentylbenzoate;Methyl olivetolate;methyl 2,4-dihydroxy-6-pentylbenzoate58016-28-7;Olivetol Methyl Ester;Methyl olivetolate Other Name Methyl 2,4-dihydroxy-6-pentylbenzoate;Benzoic acid, 2,4-dihydroxy-6-pentyl-, methyl ester;CanbidiolImpurity1;Benzoylchloride,4-chloro-5-fluoro-

58016-28-7 Chemical & Physical Properties
Melting point	105-106 °C(Solv: benzene (71-43-2))
Boiling point	409.3±30.0 °C(Predicted)
Density	1.153±0.06 g/cm3(Predicted)
Molecular Formula	C13H18O4
Molecular Weight	238.28000
solubility	Dichloromethane; Ethyl Acetate
PSA	66.76000
LogP	2.61710
Exact Mass	238.12100

Pharmaceutical Intermediates METHYL 2,4-DIHYDROXY-6-PENTYLBENZOATE 58016-28-7 Usage

Methyl Olivetolate is an intermediate in synthesizing Δ9-Tetrahydrocannabinolic Acid (Acid A & B) (T293235). It is one of the substances screened for in meconium drug testings for medicinal opiods among addicted mothers. Δ9-Tetrahydrocannabinolic Acid has been shown to protect dopaminergic neurons against 1-methyl-4-Ph pyridinium (MPP+) induced cell death.

58016-28-7 Relevant articles

Convenient syntheses of alkyl β-resorcylate derivatives

AGM Barrett, TM Morris, DHR Barton

Journal of the Chemical Society, Perkin Transactions 1

Syntheses of methyl 2,4-dihydroxy-6-methyl-(1a) and -3,6-dimethylbenzoates (1b) and methyl 2,4-dihydroxy-6-pentylbenzoate (1c) are described. Condensation reactions of dimethyl sodiomalonate with the dianion derived from pentane-2,4-dione or the dimerisation of the methyl acetoacetate dianion or the acetylation of the trianion derived from methyl 3,5,7-trioxo-octanoate gave (1a)(⩽78%) after work-up at pH 9.

Convenient Syntheses of Alkyl p-Resorcylate Derivatives

AGM Barrett, DHR Barton

Citeseer

methyl 2,4-dihydroxy-6-methyl- (1 a) and -3,6-dimethylbenzoates (1 b) and methyl 2,4-dihydroxy-6pentylbenzoate (… of the crude product gave methyl 2,4-dihydroxy-6pentylbenzoate (lc) (…

Chemistry of 1,3,5-Tris(trimethylsiloxy)-1-methoxyhexa-1,3,5-triene, a β-Tricarbonyl Trianion Equivalent

Chan, T. H.,Stoessel, D.

, p. 2423 - 2428 (2007/10/02)

The title compound has been synthesized and its chemistry studied.Condensation with orthoesters, acid chlorides, or imidazolides gave aromatic compounds in a 5C + 1C condensation.A formal synthesis of lasiodiplodin has been completed.

58016-28-7 Process route

: 18402-83-0
(E)-non-3-en-2-one

: 108-59-8
malonic acid dimethyl ester

: 58016-28-7
methyl 2,6-dihydroxy-6-pentylbenzoate

Conditions

Conditions	Yield
(E)-non-3-en-2-one; malonic acid dimethyl ester; With sodium; In methanol; at 0 ℃; for 8h; Reflux; With bromine; In N,N-dimethyl-formamide; at 0 - 80 ℃; for 17h;
(E)-non-3-en-2-one; malonic acid dimethyl ester; With sodium; In methanol; for 8h; Reflux; With bromine; In N,N-dimethyl-formamide; at 0 - 80 ℃; for 17h;