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665-66-7

Product Name:1-Adamantanamine hydrochloride
Molecular Formula:C₁₀H₁₈ClN
Appearance:Crystalline solid

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Product Details

Appearance:Crystalline solid

Purity:99%

1-Adamantanamine hydrochloride 665-66-7 Fine Crystalline Powder Supply

665-66-7 Name
Name	1-Adamantanamine hydrochloride
Synonym	Amantadine hydrochloride,1-Adamantanamine hydrochloride, 1-Adamantylamine hydrochloride, 1-Aminoadamantane hydrochloride;Amantadine Hydrochloride (200 mg);1-AdaMantanaMine hydrochloride, 99+% 100GR;1-AdaMantanaMine hydrochloride, 99+% 25GR;1-AdaMantanaMine hydrochloride, 99+% 5GR;1-adamantane amine hydrochloride;1-Adamantanamine Hydrochleride;1-Aminoadamantane Hydrochloride Amantadine Hydrochloride

665-66-7 Biological Activity

Related Catalog

Signaling Pathways >> Anti-infection >> Influenza Virus

Research Areas >> Infection

665-66-7 Chemical & Physical Properties
Melting point	>300 °C(lit.)
Boiling point	225.7ºC at 760 mmHg
Density	1.067g/cm3
Molecular Formula	C10H18ClN
Molecular Weight	187.710
Flash Point	96ºC
PSA	26.02000
LogP	3.41620
Exact Mass	187.112778
Index of Refraction	1.558
Water Solubility	soluble

1-Adamantanamine hydrochloride 665-66-7 In Medicine Usage

1-Adamantanamine hydrochloride 665-66-7, antiviral, antiparkinsonian; treatment of drug-induced extrapyrimidal reactions, is Crystalline Solid used in the prophylactic or symptomatic treatment of influenza A. It is also used as an antiparkinsonian agent, to treat extra pyramidal reactions, and for postherpetic neuralgia. 1-adamantanamine hydrochloride (ATH) is introduced to the upper surface of the perovskite film to heal the defects of the perovskite surface.

InChI:InChI=1/C10H17N/c11-10-4-7-1-8(5-10)3-9(2-7)6-10/h7-9H,1-6,11H2/t7-,8+,9-,10-

665-66-7 Relevant articles

1-Adamantanamine Hydrochloride Resists Environmental Corrosion to Obtain Highly Efficient and Stable Perovskite Solar Cells

Baibai Liu, Dongmei He, Qian Zhou, Yu Chen, Peng He, Xiao Han, Danqing Ma, Yong He, Yuelong Li, Pengjun Zhao, Zong-Xiang Xu, Shirong Lu, Zhigang Zang, and Jiangzhao Chen

J. Phys. Chem. Lett. 2023, 14, 10, 2501–2508

With obvious improvement, VOC and FF of 1.159 V and 0.796 for the control device are raised to 1.178 V and 0.826 for the ATH-modified device, respectively. Finally, during an operational stability measurement of more than 1000 h, the ATH-treated PSC exhibited better moisture resistance, thermal persistence, and light stability.

Synthetic method of amantadine hydrochloride (by machine translation)

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Paragraph 0115; 0119-0122; 0145; 0149-0156; 0157; 0162-0184, (2020/05/29)

Compared, the prior art . the synthesis method: the amantadine hydrochloride has an important clinical value and market value Ritter, and the synthesis process, of the hydrochloric acid adamantanamine, effectively improves the industrial application potential, of the hydrochloric acid adamantane hydrochloride synthesis process as, by adopting a special process and a component. The method mainly, comprises, steps of preparation of an amantadine hydrochloride synthesis process by using a special process and a method. (by machine translation)

665-66-7 Process route

: 281-23-2
adamantane

: 665-66-7,13878-11-0
amantadine hydrochloride

: 10523-68-9
adamantan-2-amine hydrochloride

Conditions

Conditions	Yield
adamantane; With methanol; cerium(III) chloride; di-tert-butyl-diazodicarboxylate; tetrabutyl-ammonium chloride; In acetonitrile; at 20 ℃; for 10h; Irradiation; Inert atmosphere; Sealed tube; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h; Reagent/catalyst; Further stages;

: 880-52-4
N-(1-adamantyl)acetamide

: 665-66-7,13878-11-0
amantadine hydrochloride

Conditions

Conditions	Yield
N-(1-adamantyl)acetamide; With sodium heptadecanoic acid; fipronilβ-cyclodextrin; sodium hydroxide; In ethanol; water; for 20h; Reflux; With hydrogenchloride; In water; at 70 ℃;	96.5%
N-(1-adamantyl)acetamide; With propylene glycol; potassium hydroxide; In water; at 125 - 130 ℃; for 8h; Green chemistry; With hydrogenchloride; In dichloromethane; water; at 55 - 60 ℃; for 1h; Temperature; Time; Green chemistry;	82%
N-(1-adamantyl)acetamide; With methanol; water; sodium hydroxide; at 145 ℃; for 8h; Autoclave; With hydrogenchloride; In dichloromethane; water; at 50 ℃; for 0.5h; Autoclave;	82.2%
N-(1-adamantyl)acetamide; With pyridine; oxalyl dichloride; In tetrahydrofuran; at 0 ℃; for 0.5h; Inert atmosphere; With propylene glycol; In tetrahydrofuran; at 0 - 25 ℃; Inert atmosphere; With hydrogenchloride; In ethanol;
N-(1-adamantyl)acetamide; With tetrabutylammomium bromide; sodium hydroxide; In water; ethylene glycol; at 190 ℃; for 12h; Autoclave; With hydrogenchloride; In water; ethylene glycol; pH=4;
N-(1-adamantyl)acetamide; With tetrabutylammomium bromide; sodium hydroxide; In water; at 190 ℃; for 12h; Autoclave; With hydrogenchloride; In water; pH=4;
Multi-step reaction with 2 steps 1: sodium hydroxide / 1,2-dimethoxyethane / 12 h / 135 °C 2: hydrogenchloride / dichloromethane; water / 3 h / 50 °C With hydrogenchloride; sodium hydroxide; In 1,2-dimethoxyethane; dichloromethane; water;