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119515-38-7

  • Product Name:Icaridin
  • Molecular Formula:C12H23NO3
  • Appearance:Colourless liquid
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Product Details

Appearance:Colourless liquid

Purity:99%

lcaridin 119515-38-7 Anophelifuge Good Price

119515-38-7 Name

Name

lcaridin

Synonym

 sec-Butyl 2-(2-hydroxyethyl)piperidine-1-carboxylate; 1-(1-methylpropoxycarbonyl)-2-(2-hydroxyethyl)piperidine;1-methylpropyl2-(2-hydroxyethyl)-1-piperidinecarboxylate;2-(2-hydroxyethyl)-1-piperidinecarboxylicaci1-methylpropylester;HYDROXYETHYL ISOBUTYL PIPERIDINE CARBOXYLATE;BAYREPELVE;2-(2-Hydroxyethyl)-1-piperidinecarboxylic Acid 1-Methyl-propyl Ester;Bayrepe;Picaridin

 

119515-38-7 Biological Activity

Related Catalog

Research Areas >> Infection

Signaling Pathways >> Others >> Others

 

119515-38-7 Chemical & Physical Properties

Melting point 

below -170ºC

Boiling point

330.9±15.0 °C at 760 mmHg

Density

1.0±0.1 g/cm3

Molecular Formula

C12H23NO3

Molecular Weight

229.316

Flash Point

 153.9±20.4 °C

PSA

49.77000

LogP

1.56

Exact Mass

229.167801

Vapour Pressure

0.0±1.6 mmHg at 25°C

Index of Refraction

1.478

119515-38-7 Usage

Icaridin, also known as picaridin or KBR 3023, is a derivative of a natural compound from pepper plants that possess high repellent effectiveness, being the most recommended active compound by the WHO. Picaridin is an insect repellent which inhibits A. aegypti odorant receptor 2 (AaOR2) or AaOR8 in the presence of their odorant activators, indole and octenol, respectively, expressed in Xenopus oocytes (IC50s = 1,452 and 1,911 μM, respectively). It acts on certain olfactory receptor cell types to reduce the activating or attracting effect of odor sources. Insect repellent

InChI:InChI=1/C12H23NO3/c1-3-10(2)16-12(15)13-8-5-4-6-11(13)7-9-14/h10-11,14H,3-9H2,1-2H3

119515-38-7 Relevant articles

Use of 2D and co-culture cell models to assess the toxicity of zein nanoparticles loading insect repellents icaridin and geraniol

T. Germano-Costa a, N. Bilesky-José , M. Guilger-Casagrande , T. Pasquoto-Stigliani , CB. Rogério , DC. Abrantes , CR. Maruyama , JL. Oliveira , LF. Fraceto , R. Lima

Colloids and Surfaces B: Biointerfaces Volume 216, August 2022, 112564

The materials used in this work were Geraniol (GER), Icaridin (ICA), Zein, Pluronic F-68, MTT (3-(4,5-dimethylthiazolyl-2)− 2,5-diphenyltetrazolium bromide), Cell Counting Kit-8 (Sigma-Aldrich). The studies of the expression of genes related to the signaling of inflammatory processes showed that TPH-1 cells in direct contact with the compounds (2D culture) present different expressions compared to those exposed in the co-culture.

119515-38-7 Process route

sec-butyl 2-(2-(((2R,3S,5R,6R)-3,5-dihydroxy-6-(hydroxymethyl)-4-oxotetrahydro-2H-pyran-2-yl)oxy)ethyl)piperidine-1-carboxylate

sec-butyl 2-(2-(((2R,3S,5R,6R)-3,5-dihydroxy-6-(hydroxymethyl)-4-oxotetrahydro-2H-pyran-2-yl)oxy)ethyl)piperidine-1-carboxylate

icaridin
119515-38-7

icaridin

Conditions
Conditions Yield
With water-d2; In aq. buffer; at 32 ℃; for 50h; pH=4; pH-value;
 
bromodifluoroacetic acid
354-08-5

bromodifluoroacetic acid

icaridin
119515-38-7

icaridin

C<sub>14</sub>H<sub>22</sub>BrF<sub>2</sub>NO<sub>4</sub>

C14H22BrF2NO4

Conditions
Conditions Yield
With oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; at 0 - 20 ℃; Inert atmosphere;
66%

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