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54492-95-4

  • Product Name:4-Benzo[b]thien-2-ylbenzenamine
  • Molecular Formula:C14H11NS
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Product Details

Purity:99%

Buy Quality 4-Benzo[b]thien-2-ylbenzenamine 54492-95-4 with Good Supplier

54492-95-4 Name

Name

4-Benzo[b]thien-2-ylbenzenamine

Synonym

 Benzenamine, 4-benzo[b]thien-2-yl-;4-Benzo[b]thien-2-ylbenzenamine

 

 Chemical & Physical Properties

Molecular Formula

C14H11NS

Molecular Weight

225.31

InChI

 The Key: KCZKJUGTTGALLE-UHFFFAOYSA-N

4-Benzo[b]thien-2-ylbenzenamine 54492-95-4 Relevant articles

Discovery of novel N-(5-(tert-butyl)isoxazol-3-yl)-N′-phenylurea analogs as potent FLT3 inhibitors and evaluation of their activity against acute myeloid leukemia in vitro and in vivo

Xu, Ying,Wang, Ning-Yu,Song, Xue-Jiao,Lei, Qian,Ye, Ting-Hong,You, Xin-Yu,Zuo, Wei-Qiong,Xia, Yong,Zhang, Li-Dan,Yu, Luo-Ting

, p. 4333 - 4343 (2015/08/03)

FLT3 inhibitors have been explored as a viable therapy for acute myeloid leukemia (AML). However, the clinical outcomes of these FLT3 inhibitors were underwhelming except AC220. Therefore, the development of novel FLT3 inhibitors with high potency against

NOVEL HETEROCYCLIC AMIDE DERIVATIVES HAVING DIHYDROOROTATE DEHYDROGENASE INHIBITING ACTIVITY

-

Page/Page column 51; 54, (2010/10/20)

Novel heterocyclic amide derivatives having pharmacological effects, that is, compounds represented by the general formula (1) or salts thereof: (1) wherein X1-X2 is S-CH2 or the like; R1 is alkyl or the like; p is 0 to 7; R2 is hydrogen, alkyl, or the like; R3 is hydrogen, alkyl, or the like; Y1-Y2 is CH=CH or the like; R4 is halogeno, alkyl, or the like; q is 0 to 4; and R5 is halogeno, hydrogen, alkyl, or the like.

54492-95-4 Process route

benzo[b]thiophene-2-boronic acid
98437-23-1

benzo[b]thiophene-2-boronic acid

2-(4-aminophenyl)benzothiophene
54492-95-4

2-(4-aminophenyl)benzothiophene

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: sodium phosphate dodecahydrate; palladium 10% on activated carbon / water; isopropyl alcohol / 4 h / 80 °C / Inert atmosphere
2: iron; ammonium chloride / ethanol; water / 1 h / Reflux
With sodium phosphate dodecahydrate; palladium 10% on activated carbon; iron; ammonium chloride; In ethanol; water; isopropyl alcohol; 1: |Suzuki Coupling;
 
para-nitrophenyl bromide
586-78-7

para-nitrophenyl bromide

2-(4-aminophenyl)benzothiophene
54492-95-4

2-(4-aminophenyl)benzothiophene

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: sodium phosphate dodecahydrate; palladium 10% on activated carbon / water; isopropyl alcohol / 4 h / 80 °C / Inert atmosphere
2: iron; ammonium chloride / ethanol; water / 1 h / Reflux
With sodium phosphate dodecahydrate; palladium 10% on activated carbon; iron; ammonium chloride; In ethanol; water; isopropyl alcohol; 1: |Suzuki Coupling;
 

54492-95-4 Upstream products

  • 98437-23-1
    98437-23-1

    benzo[b]thiophene-2-boronic acid

  • 586-78-7
    586-78-7

    para-nitrophenyl bromide

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