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53014-84-9

  • Product Name:3-Pyridinecarboxaldehyde,6-methyl-
  • Molecular Formula:C7H7NO
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Product Details

Purity:99%

High Purity 3-FORMYL-6-METHYL-PYRIDINE 53014-84-9 Liquid

53014-84-9 Name

Name

3-FORMYL-6-METHYL-PYRIDINE

Synonym

 6-METHYL-3-PYRIDINECARBOXALDEHYDE;5-FORMYL-2-PICOLINE;3-FORMYL-6-METHYL-PYRIDINE;6-Methylpyridine-3-carboxaldehyde;5-Formyl-2-methylpyridine;6-Methylnicotinaldehyde;3-Pyridinecarboxaldehyde, 6-methyl-;3-Formyl-6-methyl-pyridine ,97%

 

53014-84-9 Chemical & Physical Properties

Boiling point

213.7±20.0 °C at 760 mmHg

Density

1.1±0.1 g/cm3

Molecular Formula

C7H7NO

Molecular Weight

121.137

Flash Point

 87.6±29.2 °C

PSA

29.96000

LogP

1.03

Exact Mass

121.052765

Appearance of Characters

Liquid

Vapour Pressure

0.2±0.4 mmHg at 25°C

Index of Refraction

1.563

3-FORMYL-6-METHYL-PYRIDINE 53014-84-9 Liquid Usage

InChI:InChI=1/C7H7NO/c1-6-2-3-7(5-9)4-8-6/h2-5H,1H3

53014-84-9 Relevant articles

Bromine-magnesium exchange of 5-bromo-2-picoline via an organomagnesium complex nBu2iPrMgLi: A new preparation methodology of functionalized picolines under noncryogenic conditions

Kii, Satoshi,Akao, Atsushi,Iida, Takehiko,Mase, Toshiaki,Yasuda, Nobuyoshi

, p. 1877 - 1879 (2006)

The organomagnesium complex nBu2iPrMgLi, readily prepared from nBuLi and iPrMgCl (2:1), is quite efficient for the bromine-magnesium exchange of 5-bromo-2-picoline under noncryogenic conditions (at -10°C). The resulting picolylmagnesium complex reacts with various electrophiles to afford functionalized picolines.

2,6-DIOXO,-2,3-DIHYDRO-1H-PURINE COMPOUNDS USEFUL FOR TREATING DISORDERS RELATED TO THE ACTIVITY OF THE TRPA1 CHANNEL

-

, (2017/07/14)

Compounds of formula (VIII) and compositions for treating disorders related to TRPA1 are described herein.

KYNURENINE PRODUCTION INHIBITOR

-

, (2011/10/12)

Provided is a kynurenine production inhibitor comprising a nitrogen-containing heterocyclic compound represented by formula (I): (wherein R50 and R51 may be the same or different and each represent a hydrogen atom or the like, G1 and G2 may be the same or different and each represent a nitrogen atom or the like, X represents formula (III): (wherein m1 and m2 may be the same or different and each represent an integer of 0 or 1, Y represents an oxygen atom or the like, and R6 and R7 may be the same or different and each represent a hydrogen atom or the like), R1 represents optionally substituted lower alkyl or the like, R2 represents a hydrogen atom or the like, and R3 represents optionally substituted lower alkyl or the like), and the like.

53014-84-9 Process route

6-methyl-3-pyridinemethanol
34107-46-5

6-methyl-3-pyridinemethanol

2-methyl-5-formylpyridine
53014-84-9

2-methyl-5-formylpyridine

Conditions
Conditions Yield
6-methyl-3-pyridinemethanol; With oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; at -60 ℃; for 1.33333h;
With triethylamine; In dichloromethane; at -60 - 20 ℃; for 0.166667h;
85%
With oxalyl dichloride; dimethyl sulfoxide; triethylamine; In dichloromethane; at -60 ℃; for 1.5h;
85%
With lead(IV) acetate; In toluene; for 2.5h; Heating;
57%
With oxalyl dichloride; dimethyl sulfoxide; triethylamine; Yield given. Multistep reaction; 1.) methylene chloride, -60 deg C, 20 min, 2.) from -60 deg C to RT;
 
In pyridine; water;
 
With manganese(IV) oxide; In dichloromethane; at 25 ℃; for 68h;
 
In pyridine; water;
 
With manganese(IV) oxide; In dichloromethane; at 0 - 20 ℃; for 1.25h;
 
With Chloro-oxo-acetic acid; dimethyl sulfoxide; In dichloromethane; at -78 ℃; for 0.166667h;
6-methyl-3-pyridinemethanol; In dichloromethane; at -78 ℃; for 2.5h;
With triethylamine; In dichloromethane; at -78 - 20 ℃;
 
5-bromo-2-methylpyridine
3430-13-5

5-bromo-2-methylpyridine

N,N-dimethyl-formamide
68-12-2,33513-42-7

N,N-dimethyl-formamide

2-methyl-5-formylpyridine
53014-84-9

2-methyl-5-formylpyridine

Conditions
Conditions Yield
5-bromo-2-methylpyridine; With n-butyllithium; isopropylmagnesium chloride; In tetrahydrofuran; hexane; at -10 ℃; for 0.5h;
N,N-dimethyl-formamide; In tetrahydrofuran; at 0 ℃; for 2h;
85%
5-bromo-2-methylpyridine; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 1h;
N,N-dimethyl-formamide; In tetrahydrofuran; at -78 ℃; for 1h;
72%
5-bromo-2-methylpyridine; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 1h;
N,N-dimethyl-formamide; In tetrahydrofuran; at -78 ℃; for 1h;
72%
5-bromo-2-methylpyridine; With n-butyllithium; isopropylmagnesium chloride; In tetrahydrofuran; hexane; at 10 ℃; for 1h;
N,N-dimethyl-formamide; In tetrahydrofuran; hexane; at 20 ℃; for 2h;
38%
5-bromo-2-methylpyridine; With isopropylmagnesium chloride; In tetrahydrofuran; at 0 - 20 ℃; for 6h;
N,N-dimethyl-formamide; In tetrahydrofuran; at 0 - 20 ℃;
4.5 g

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