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Purity:99%
5-BROMO-2,4-DIFLUORO is a useful chemical material.
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473416-91-0 Name |
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Name |
5-BROMO-2,4-DIFLUORO |
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Synonym |
5-BroMo-2,4-difluorobenzaldehyde;BENZALDEHYDE, 5-BROMO-2,4-DIFLUORO |
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473416-91-0 Chemical & Physical Properties |
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Boiling point |
229.4±35.0 °C(Predicted) |
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Density |
1.758±0.06 g/cm3(Predicted) |
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Molecular Formula |
C7H3BrF2O |
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Molecular Weight |
220.99900 |
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PSA |
17.07000 |
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LogP |
2.53980 |
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Exact Mass |
219.93400 |
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storage temp. |
under inert gas (nitrogen or Argon) at 2-8°C |
The present invention covers 4-(3-amino-6-fluoro-1H-indazol-5-yl)-1,2,6-trimethyl-1,4- dihydropyridine-3,5-dicarbonitrile compounds of general formula (I) : in which R1, R2 and R3 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment and/or prophylaxis of diseases.
Compounds of formula (I), including pharmaceutically acceptable salts thereof, are set forth herein: wherein R1, R2, R3, R4, R5, and R6 are independently hydrogen, C1-C6 alkyl or C1-C6 cycloalkyl; Y and Z are independently a C6-C10- aryl group or a 5-10 membered heterocyclic group, wherein each Y and Z group can be optionally substituted with from 0-3 substituents selected from halogen, amino, C1-4alkylamino, C1-4dialkylamino, haloC1-4 alkyl, OH, CN, C1-C6 alkyl or cycloalkyl, C1-C6 alkoxy, and C2-C4 alkynyl; L is either a bond or is -NHCO-; L and Z together can be absent; and m is 1, 2 or 3.
1,5-dibromo-2,4-difluorobenzene
N,N-dimethyl-formamide
5-bromo-2,4-difluorobenzaldehyde
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1,5-dibromo-2,4-difluorobenzene; With n-butyllithium; In diethyl ether; hexane; at -70 ℃; for 0.5h; Cooling with ether-dry ice;
N,N-dimethyl-formamide; In diethyl ether; hexane; at -70 - 0 ℃; for 0.5h;
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77% |
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1,5-dibromo-2,4-difluorobenzene; With n-butyllithium; In diethyl ether; hexane; at -78 ℃; for 0.25h;
N,N-dimethyl-formamide; In diethyl ether; hexane; at -78 - 20 ℃; for 1.25h;
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70% |
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With butyl lithium; In diethyl ether; hexane; at -78 ℃; for 0.25h;
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61% |
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1,5-dibromo-2,4-difluorobenzene; With n-butyllithium; In diethyl ether; at -78 ℃; for 0.5h;
N,N-dimethyl-formamide; In diethyl ether; at -78 ℃; for 0.5h;
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60% |
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1,5-dibromo-2,4-difluorobenzene; With n-butyllithium; In diethyl ether; at -78 ℃; for 0.583333h;
N,N-dimethyl-formamide; In diethyl ether; at -78 ℃; for 0.5h;
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60% |
N,N-dimethyl-formamide
5-bromo-2,4-difluorobenzaldehyde
| Conditions | Yield |
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1,5-dibromo-2,4-difluorobenzene; With n-butyllithium; In diethyl ether; hexane; at -78 ℃; for 0.5h;
N,N-dimethyl-formamide; In diethyl ether; hexane; at -78 ℃; for 0.5h;
With acetic acid; In diethyl ether; hexane; water;
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N,N-dimethyl-formamide
1,5-dibromo-2,4-difluorobenzene
2,4-difluorobromobenzene
2,4-difluoro-5-formylbenzonitrile
5-((tert-butyldimethylsilyl)oxy)-1-(2,4-difluoro-5-(pyrimidin-5-yl)phenyl)-2-methylenepentan-1-one
(R)-N-((2S,4R)-2-(2,4-difluoro-5-(pyrimidin-5-yl)phenyl)-4-(3,5-dimethylisoxazol-4-yl)-4-hydroxybutan-2-yl)-2-methylpropane-2-sulfinamide
(1R,3S)-3-amino-3-(2,4-difluoro-5-(pyrimidin-5-yl)phenyl)-1-(3,5-dimethylisoxazol-4-yl)butan-1-ol
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