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19094-56-5

Product Name:Benzoicacid, 2-chloro-5-iodo-
Molecular Formula:C₇H₄ClIO₂
Appearance:white to light yellow crystal powder

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Product Details

Appearance:white to light yellow crystal powder

Purity:99%

High Quality 2-Chloro-5-iodobenzoic acid 19094-56-5

19094-56-5 Name
Name	2-Chloro-5-iodobenzoic acid
Synonym	2-CHLORO-5-IODOBENZOIC ACID;BUTTPARK 100\01-43;2-Chloro-5-iodobenzoic acid, 98+%;SOTA-011;2 - chloro - 5 - iodine benzoic acid;Chloro-5-iodobenzoicA;2-Chloro-5-iodobnezoic Acid;2-choloro-5-iodobenzoicacid

19094-56-5 Chemical & Physical Properties
Melting point	157-161 °C(lit.)
Boiling point	353.1±27.0 °C at 760 mmHg
Density	2.1±0.1 g/cm3
Molecular Formula	C7H4ClIO2
Molecular Weight	282.463
Flash Point	167.4±23.7 °C
PSA	37.30000
LogP	3.18
Exact Mass	281.894440
Vapour Pressure	0.0±0.8 mmHg at 25°C
Index of Refraction	1.673

Pharmaceutical Intermediates 2-Chloro-5-iodobenzoic acid 19094-56-5 Usage

2-Chloro-5-iodobenzoic acid is white to light yellow crystal powder, which is used as starting material.

InChI:InChI=1/C7H4ClIO2/c8-6-2-1-4(9)3-5(6)7(10)11/h1-3H,(H,10,11)

19094-56-5 Relevant articles

Synthesis of Benzyl C-Analogues of Dapagliflozin as Potential SGLT2 Inhibitors

Aidhen, Indrapal Singh,Banerjee, Sanjay K.,Kumar, Roshan,Mukkamala, Ramesh

, (2020)

Sodium-glucose co-transporter (SGLT) inhibitors are a novel class of therapeutic agents for the treatment of type 2 diabetes based on blocking of renal reabsorption of glucose. Dapagliflozin, a C-aryl glucoside, has emerged as a successful drug in the market based on this concept. These results presented herein amply demonstrate the promise of C-benzyl analogues of Dapagliflozin as novel SGLT2 inhibitors for future investigations.

Design, synthesis and anticancer activities of halogenated Phenstatin analogs as microtubule destabilizing agent

S Hu, W Sun, Y Wang, H Yan

Medicinal Chemistry Research, 2019

It was synthesized within three steps starting from 2-chloro-5-iodobenzoic acid and substituted benzene. The microtubule destabilizing activities were evaluated in vitro with human liver cancer Huh-7 cell line and human lung cancer A549 cell line. Some of the HPAs were achieved IC50 about 5.0 μM against human liver cancer Huh-7 cells.

19094-56-5 Process route

: 89-54-3
2-chloro-5-aminobenzoic acid

: 19094-56-5
2-chloro-5-iodobenzoic acid

Conditions

Conditions	Yield
2-chloro-5-aminobenzoic acid; With sulfuric acid; sodium nitrite; In water; at 0 - 10 ℃; With urea; potassium iodide; In water; at 0 ℃; for 0.5h;	93.7%
With toluene-4-sulfonic acid; sodium iodide; In water; acetonitrile; at 10 - 20 ℃; for 2h; Inert atmosphere;	79%

: 118-91-2
ortho-chlorobenzoic acid

: 19094-56-5
2-chloro-5-iodobenzoic acid

Conditions

Conditions	Yield
With potassium iodate; sulfuric acid; iodine; In dichloromethane; at 25 - 30 ℃; for 1h; Reagent/catalyst;	69.6%
Multi-step reaction with 3 steps 1.1: nitric acid; sulfuric acid / 2 h / -5 - 5 °C 2.1: iron; ammonium chloride / ethanol; water / 5 h / 78 - 80 °C 3.1: sodium nitrite; sulfuric acid / water / 0 - 10 °C 3.2: 0.5 h / 0 °C With sulfuric acid; nitric acid; iron; ammonium chloride; sodium nitrite; In ethanol; water;