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41100-52-1

  • Product Name:Memantine HCL
  • Molecular Formula:C12H21N.HCl
  • Appearance:Crystalline solid
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Product Details

Appearance:Crystalline solid

Purity:99%

Fast Delivery Memantine HCL 41100-52-1

41100-52-1 Name

Name

Memantine HCL

Synonym

 MEMANTINE HCL;LABOTEST-BB LT00233220;1,3-Dimethyl-5-aminoadamantane hydrochloride;1,3-DIMETHYLAMINOADAMANTANE HYDROCHLORIDE;1-AMINO-3,5-DIMETHYLADAMANTANE HCL;1-AMINO-3,5-DIMETHYLADAMANTANE HYDROCHLORIDE;1-AMINO-3,4-DIMETHYLADAMANTANE HYDROCHLORIDE;3,5-DIMETHYLAMANTADINE HYDROCHLORIDE  

 

41100-52-1 Biological Activity

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41100-52-1 Chemical & Physical Properties

Melting point 

292 °C

Boiling point

239.8ºC at 760 mmHg

Molecular Formula

C12H22ClN

Molecular Weight

215.763

Flash Point

 92.3ºC

PSA

26.02000

LogP

4.19640

Exact Mass

215.144073

Storage condition

-20°C Freezer

Memantine HCL 41100-52-1 In Stock

Memantine HCl is the HCl form of Memantine. Memantine hydrochloride, also often known to as 1-amino-3,5-dimethyl-adamantane hydrochloride , is a novel drug used to treat Alzheimer's disease. Memantine hydrochloride (Namenda; Forest/Merz), which acts to protect neurons against toxicity caused by overactivation of N-methyl-D-aspartate receptors. Memantine HCl (ME-HCl) is a novel class of Alzheimer’s disease medication acting on glutamatergic system by blocking NMDA glutamate receptors.

InChI:InChI=1/C12H21N.ClH/c1-10-3-9-4-11(2,6-10)8-12(13,5-9)7-10;/h9H,3-8,13H2,1-2H3;1H

41100-52-1 Relevant articles

Investigations on molecular interactions of memantine hydrochloride in aqueous solutions by thermophysical methods and molecular dynamics simulations at different temperatures

Yesupadamu Rayinuthala , David Raju M , Munnangi Srinivasa Reddy , Nayeem Sk Md , Rameez Arhan Sk Md

Journal of the Indian Chemical Society Volume 100, Issue 4, April 2023, 100967

The density (ρ), speed of sound (u), and refractive index (nD) of aqueous solutions of Memantine hydrochloride with molalities ranging from 0.0 to 0.05 at atmospheric pressure and temperatures between 305.15 and 320.15 K were investigated. A thorough review of the literature indicates a paucity of data on volumetric properties of aqueous solutions of memantine hydrochloride. Consequently, we intended on conducting investigations on memantine hydrochloride in water that included volumetric, optical, and molecular dynamic studies at different temperatures.

Cerium-Catalyzed C-H Functionalizations of Alkanes Utilizing Alcohols as Hydrogen Atom Transfer Agents

An, Qing,Chen, Yuegang,Liu, Weimin,Pan, Hui,Wang, Xin,Wang, Ziyu,Zhang, Kaining,Zuo, Zhiwei

supporting information, p. 6216 - 6226 (2020/04/27)

Modern photoredox catalysis has traditionally relied upon metal-to-ligand charge-transfer (MLCT) excitation of metal polypyridyl complexes for the utilization of light energy for the activation of organic substrates. Furthermore, the LMCT excitation event has been investigated through a series of spectroscopic experiments, revealing a rapid bond homolysis process and an effective production of alkoxy radicals, collectively ruling out the LMCT/homolysis event as the rate-determining step of this C-H functionalization.

41100-52-1 Process route

3,5-dimethyl-1-bromoadamantane
941-37-7

3,5-dimethyl-1-bromoadamantane

memantine hydrochloride
41100-52-1

memantine hydrochloride

Conditions
Conditions Yield
3,5-dimethyl-1-bromoadamantane; With sulfuric acid; toluene-4-sulfonic acid; acetonitrile; at 30 - 50 ℃; for 2h;
With hydrogenchloride; In water; ethyl acetate; for 2h; Reagent/catalyst;
88.44%
3,5-dimethyl-1-bromoadamantane; With formic acid; urethane; at 20 - 90 ℃; for 1h; Inert atmosphere;
With hydrogenchloride; In water; at 20 - 110 ℃; for 4h; Reagent/catalyst; Temperature; Inert atmosphere;
85%
Multi-step reaction with 3 steps
1: sulfuric acid / 12 h
2: sodium hydroxide / water; ethylene glycol / 12 h / 150 °C
3: hydrogenchloride / pH 6 / Gas phase
With hydrogenchloride; sulfuric acid; sodium hydroxide; In water; ethylene glycol;
 
Multi-step reaction with 3 steps
1: 125 °C
2: potassium hydroxide / butan-1-ol / 120 °C / Inert atmosphere
3: hydrogenchloride / acetone; water / 0 - 10 °C
With hydrogenchloride; potassium hydroxide; In water; acetone; butan-1-ol;
 
Multi-step reaction with 2 steps
1.1: 14 h / 157 °C
1.2: 5 - 25 °C
2.1: hydrogenchloride / water / 8 h / 2 - 102 °C
With hydrogenchloride; In water;
 
Multi-step reaction with 2 steps
1: formamide / 8 h / 155 °C
2: hydrogenchloride / water / 8 h / 2 - 102 °C
With hydrogenchloride; formamide; In water;
 
Multi-step reaction with 4 steps
1.1: 14 h / 157 °C
1.2: 5 - 25 °C
2.1: hydrogenchloride / water / 21 h / 28 °C
3.1: 10 h / 152 °C
4.1: hydrogenchloride / water / 8 h / 2 - 102 °C
With hydrogenchloride; In water;
 
Multi-step reaction with 4 steps
1: formamide / 8 h / 155 °C
2: hydrogenchloride / water / 21 h / 28 °C
3: 10 h / 152 °C
4: hydrogenchloride / water / 8 h / 2 - 102 °C
With hydrogenchloride; formamide; In water;
 
Multi-step reaction with 2 steps
1.1: phosphoric acid / 3.75 - 4.33 h / 20 - 87 °C
1.2: 35 - 45 °C / pH 5.5 - 7
2.1: potassium hydroxide; butan-1-ol / 10.33 - 10.5 h / 20 - 132 °C
2.2: 0.67 h / 20 - 25 °C
With potassium hydroxide; phosphoric acid; butan-1-ol;
 
Multi-step reaction with 2 steps
1.1: sulfuric acid / 15.5 - 16 h / 10 - 35 °C
1.2: 20 °C
2.1: sodium hydroxide / diethylene glycol / 10 h / Heating / reflux
2.2: 2 h / 10 - 15 °C
With sodium hydroxide; sulfuric acid; In diethylene glycol;
 
Multi-step reaction with 3 steps
1.1: sulfuric acid / 22 h / 10 - 25 °C
1.2: 1.5 h / 25 - 35 °C
2.1: ammonia / dichloromethane; water / 0.5 h / 25 - 30 °C / pH 9.5 - 10.0
3.1: sodium hydroxide / diethylene glycol / 10 h / Heating / reflux
3.2: 2 h / 10 - 15 °C
With sodium hydroxide; sulfuric acid; ammonia; In dichloromethane; water; diethylene glycol;
 
Multi-step reaction with 3 steps
1: 6 h / 70 - 160 °C / Inert atmosphere
2: potassium hydroxide / butan-1-ol / 10.5 h / 130 °C / Inert atmosphere
3: hydrogenchloride / water; acetone / 5 h / -5 - 30 °C
With hydrogenchloride; potassium hydroxide; In water; acetone; butan-1-ol;
 
Multi-step reaction with 2 steps
1.1: 8 h / 130 °C
2.1: potassium hydroxide; butan-1-ol / 130 °C
2.2: pH 8 - 9
With potassium hydroxide; butan-1-ol;
 
1-nitro-3,5-dimethyl-adamantane
6588-68-7

1-nitro-3,5-dimethyl-adamantane

memantine hydrochloride
41100-52-1

memantine hydrochloride

Conditions
Conditions Yield
1-nitro-3,5-dimethyl-adamantane; With hydrogen; In ethanol; at 80 ℃; for 0.5h; under 750.075 - 18751.9 Torr; Autoclave;
With hydrogenchloride; for 0.5h;
97.4%
1-nitro-3,5-dimethyl-adamantane; With iron; acetic acid; at 20 ℃; for 4.5h;
With hydrogenchloride; In ethyl acetate; for 0.5h;
449.2 g

41100-52-1 Upstream products

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41100-52-1 Downstream products

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    4-((tert-butoxycarbonyl)(3,5-dimethyladamantan-1-yl)amino)butyl 4-methylbenzenesulfonate

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